There have been various studies finished with fathead minnows. Because they are hardy, and also replicate in multitudes, they are additionally relied on as trial fish in researches to comprehend the results of chemicals on vertebrate pets. One was a research the impacts of reduced pH. While they made it through, they did act unpredictably. They would be hyperactive. They would likewise swim close to the surface. And, they experienced some problems with reproducing as their heads ended up being smaller sized and they shed a few of their brightness. The eggs were also less most likely to hatch. In another instance, when subjected to cattle barnyard waste, males were feminized and also girls defeminized.

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The fathead minnow has an alarm system that releases a compound called Schreckstoff when particular cells are injured in an attack. Then, this launched material is identified by the killer fish which then will certainly hide or dart away. This system assists fathead minnows realized possible killers. The fathead's key predator is the northern pike, and also this chemical recognition capability assists the minnow recognize its predators.